AlphaFold 3 (AF3), developed by Google DeepMind, represents a major advancement in the field of biomolecular structure prediction. It is a state-of-the-art AI tool specifically designed to predict and analyze the three-dimensional structures of complex biomolecules and their interactions, encompassing proteins, DNA, RNA, and other biomolecules. AF3 transcends the limitations of previous versions by employing […]
Author: starrcofly
Computational Biologist
In recent years, artificial intelligence (AI) technology has advanced rapidly, especially with the increasingly widespread application of large models such as GPT-4, Claude, Gemini, WuDao 2.0, ERNIE, and PanGu-α. From natural language processing to image recognition and autonomous driving, AI large models have demonstrated immense potential across various fields. However, despite their outstanding capabilities in […]
I. Generation of Simulation Data: To clearly present the analysis results, post-infection clinical symptoms of the virus are simulated using the common case-control pattern, simulating both severe and mild patients. Considering that some clinical phenotypic data (such as age) are highly correlated with post-infection symptoms, we set up 2 strongly correlated features. Additionally, we established […]
Let’s start by comparing two common concepts, bioinformatics and computational biology. Bioinformatics actually originated in 1978 as a new concept proposed by Paulien Hogeweg: Theoretical Biology, which refers to a biological existence that is theoretical (generated by computation) and corresponds to experimental results. Today, bioinformatics has a clear positioning: it’s a tool-based discipline, specifically, the […]
The design of high-throughput biological experiments requires careful consideration of various key factors to ensure the experiment’s effectiveness and reproducibility. High-throughput experiments, such as genomic sequencing, proteomics analyses, or cytomics studies, typically involve large numbers of samples and complex data analysis. Below are some important considerations: Clear Experimental Objectives Sample Selection and Processing Experimental Design […]